C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure

Figure 5 C5aR signaling induces SphK1 expression through activation of p38-MAPK. A: C5a induced p38-MAPK activation in liver tissue of acute liver failure (ALF) mice; B: PEMs were stimulated with C5a (500 ng/mL) or C5a + C5aRa (pre-incubated 60 min with 10 nmol/L of C5aRa in the presence of C5a); C: Inhibition of p38-MAPK activity with SB203580 down-regulated SphK1 expression in PEMs stimulated with C5a.