Non-invasive evaluation of liver stiffness after splenectomy in rabbits with CCl4-induced liver fibrosis

Table 7 Longitudinal changes in liver function between splenectomy and sham groups

		POW 0	POW 2	POW 4	POW 6	POW 8	POW 10
AST (IU/L)
F1	Group S (n = 5)	138.0 ± 87.3	236.7 ± 110.6	484.3 ± 244.2	307.3 ± 138.9	454.0 ± 291.3	574.3 ± 350.6
	Group L (n = 4)	447.0 ± 292.7	245.5 ± 98.3	589.5 ± 140.7	455.0 ± 309.7	517.5 ± 55.9	470.0 ± 155.6
F2	Group S (n = 4)	353.6 ± 208.4	473.4 ± 212.1	426.0 ± 186.4	448.6 ± 286.4	658.2 ± 221.9	575.6 ± 104.4
	Group L (n = 4)	392.0 ± 290.5	493.5 ± 269.0	407.5 ± 100.4	506.3 ± 156.8	494.5 ± 88.8	550.0 ± 125.6
F3	Group S (n = 4)	578.3 ± 219.5	681.3 ± 208.9	534.0 ± 292.2	622.7 ± 286.2	584.7 ± 144.5	713.3 ± 122.8
	Group L (n = 4)	598.8 ± 219.5	569.8 ± 208.9	651.5 ± 292.2	513.0 ± 286.2	435.5 ± 144.5	831.8 ± 122.8
F4	Group S (n = 3)	562.2 ± 356.6	604.2 ± 314.3	578.4 ± 247.7	623.8 ± 101.1	672.6 ± 122.6	525.6 ± 153.2
	Group L (n = 3)	412.6 ± 190.9	508.7 ± 253.8	604.0 ± 121.8	616.7 ± 203.1	571.0 ± 145.7	480.3 ± 91.4
ALT (IU/L)
F1	Group S (n = 5)	88.7 ± 39.2	270.3 ± 144.9	460.7 ± 227.5	379.0 ± 179.2	526.7 ± 185.8	440.7 ± 220.4
	Group L (n = 4)	195.0 ± 39.6	322.0 ± 76.4	430.5 ± 2.1	445.0 ± 108.9	560.5 ± 87.0	372.0 ± 198.0
F2	Group S (n = 4)	224.6 ± 187.8	240.8 ± 96.7	355.8 ± 165.8	342.6 ± 165.1	436.8 ± 74.9	458.0 ± 92.4
	Group L (n = 4)	291.8 ± 65.9	364.3 ± 86.5	310.3 ± 35.8	414.5 ± 136.8	473.3 ± 140.5	498.3 ± 174.0
F3	Group S (n = 4)	315.7 ± 232.7	434.0 ± 171.8	528.3 ± 137.7	588.0 ± 61.6	461.3 ± 208.2	497.3 ± 73.6
	Group L (n = 4)	477.8 ± 151.7	484.0 ± 34.4	459.3 ± 132.5	601.0 ± 274.9	488.8 ± 210.2	507.0 ± 133.2
F4	Group S (n = 3)	416.8 ± 286.2	490.6 ± 43.3	626.2 ± 93.0	478.0 ± 83.3	550.6 ± 252.5	519.2 ± 44.9
	Group L (n = 3)	529.0 ± 167.0	475.8 ± 106.7	600.4 ± 116.3	512.6 ± 207.8	576.8 ± 233.1	695.4 ± 150.6
Albumin (g/L)
F1	Group S (n = 5)	41.6 ± 2.4	40.5 ± 1.8	39.4 ± 2.3	40.5 ± 3.4	40.0 ± 2.0	39.8 ± 1.7
	Group L (n = 4)	41.3 ± 4.9	40.2 ± 3.0	40.3 ± 1.8	39.3 ± 0.6	39.3 ± 2.0	40.7 ± 1.3
F2	Group S (n = 4)	39.0 ± 1.9	38.3 ± 1.9	38.3 ± 1.5	38.9 ± 2.0	38.9 ± 1.6	38.9 ± 0.8
	Group L (n = 4)	39.6 ± 1.6	39.6 ± 1.7	38.0 ± 1.5	39.5 ± 0.8	39.0 ± 1.4	38.9 ± 1.9
F3	Group S (n = 4)	30.7 ± 4.3	30.3 ± 3.9	29.8 ± 3.3	31.0 ± 3.0	30.2 ± 3.8	30.5 ± 4.1
	Group L (n = 4)	31.1 ± 5.7	30.8 ± 5.1	31.8 ± 4.6	30.6 ± 5.2	30.9 ± 4.9	30.3 ± 4.2
F4	Group S (n = 3)	35.8 ± 5.6	36.0 ± 4.7	34.5 ± 4.1	34.2 ± 4.8	35.1 ± 5.1	35.5 ± 3.6
	Group L (n = 3)	35.3 ± 6.6	34.9 ± 5.8	35.4 ± 6.1	34.8 ± 3.4	34.8 ± 4.9	35.0 ± 5.6
TB (μmol/L)
F1	Group S (n = 5)	1.08 ± 0.10	1.30 ± 0.16	1.60 ± 0.16	1.58 ± 0.18	1.71 ± 0.23	1.70 ± 0.22
	Group L (n = 4)	1.34 ± 0.16	1.38 ± 0.08	1.39 ± 0.08	1.65 ± 0.20	1.51 ± 0.19	1.58 ± 0.25
F2	Group S (n = 4)	2.01 ± 0.72	2.35 ± 0.58	2.45 ± 0.61	2.65 ± 0.47	2.76 ± 0.51	2.81 ± 0.54
	Group L (n = 4)	2.08 ± 0.23	2.45 ± 0.51	2.62 ± 0.45	2.67 ± 0.23	2.99 ± 0.15	2.68 ± 0.40
F3	Group S (n = 4)	2.36 ± 0.64	2.52 ± 0.64	2.62 ± 0.51	2.66 ± 0.29	2.97 ± 0.19	3.09 ± 0.10
	Group L (n = 4)	2.59 ± 0.76	2.87 ± 0.42	2.88 ± 0.48	2.94 ± 0.33	3.13 ± 0.20	3.09 ± 0.12
F4	Group S (n = 3)	2.30 ± 0.56	2.58 ± 0.54	2.73 ± 0.22	2.88 ± 0.18	3.05 ± 0.26	3.03 ± 0.38
	Group L (n = 3)	2.35 ± 0.84	2.49 ± 0.52	2.82 ± 0.67	2.96 ± 0.13	3.11 ± 0.48	3.08 ± 0.51

POW: Postoperative weeks; Group S: Rabbits received splenectomy plus liver biopsy; Group L: Rabbits received liver biopsy only.