Non-invasive evaluation of liver stiffness after splenectomy in rabbits with CCl4-induced liver fibrosis

Table 3 Basic characteristics of rabbits with different liver fibrosis stages in Experiment 1

Parameters	F0 (n = 8)	F1 (n = 11)	F2 (n = 16)	F3 (n = 16)	F4 (n = 25)
Body weight (kg)	2.34 ± 0.24	2.28 ± 0.27	2.39 ± 0.14	2.30 ± 0.38	2.24 ± 0.33
Type IV collagen (μg/L)	200.8 ± 131.5	427.1 ± 226.2	683.4 ± 332.5	1161.4 ± 482.5	1292.0 ± 689.7
Hyaluronic acid (μg/L)	225.6 ± 117.1	475.7 ± 296.4	676.2 ± 274.8	724.0 ± 264.5	1182.3 ± 1091.3
TB (μmol/L)	0.98 ± 0.53	1.91 ± 0.63	2.20 ± 0.85	1.81 ± 0.82	1.64 ± 0.91
AST (IU/L)	26.8 ± 14.7	345.0 ± 295.9	449.2 ± 304.7	666.4 ± 428.3	616.1 ± 609.2
ALT (IU/L)	14.0 ± 3.7	254.7 ± 194.0	301.5 ± 210.7	456.3 ± 316.0	486.5 ± 295.8
Albumin (g/L)	42.7 ± 4.9	40.4 ± 4.6	36.5 ± 4.3	32.3 ± 6.4	35.3 ± 5.9
LSM (kPa)	7.88 (6.60-8.46)	8.46 (6.22-10.35)	10.89 (8.09-14.46)	18.62 (16.03-21.16)	25.10 (20.28-30.95)

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; LSM: Liver stiffness measurement; TB: Total bilirubin.