Non-invasive evaluation of liver stiffness after splenectomy in rabbits with CCl4-induced liver fibrosis

Table 1 Detailed information on the experimental process

Modeling time	Distribution of operation	Humane	Rabbits	POW 2	POW 4	POW 6	POW 8	POW 10	Humane	Exclusion	Death	Rabbits
		Termination1	left2						Termination3			left4
0W	/	0	90	/	/	/	/	/	/	/	/	/
2W	/	0	90	/	/	/	/	/	/		/	/
4W	AAAA	0	82	AAAA	AAAA	AAA5	AA	AA	1	1	1	5
	BBBB			BBB	BBB	BBB	BBB	BBB
6W	AAAA	0	74	AAA	AAA	AAA	AA	AA	2	0	2	4
	BBBB			BBBB	BBB	BBB	BB	BB
8W	AAAA	2	64	AAA	AA	AA	AA	AA	2	0	1	4
	BBBB5			BBB	BBB	BB	BB	BB
10W	AAAA	3	53	AAA	AAA	AA	AA	AA	2	1	1	4
	BBBB			BBBB	BBB	BBB5	BB	BB
12W	AAAA	3	42	AAA	AAA	AA	AA	AA	3	0	1	4
	BBBB			BBB	BB	BB	BB	BB
14W	AAAA	2	32	AAA	AA	AA	AA	A	5	0	0	2
	BBBB5			BBB	BBB	BB	B	B
16W	AAAA	4	20	AAAA	AAA	AAA	AA	AA	4	0	1	3
	BBBB			BBB	BB	BB	BB	B
18W	AAAA	3	9	AAA	AAA	AAA	AA	AA	4	0	0	3
	BBBB5			BBB	BB	BB	B	B
20W	AAAA	2	0	AA	AA	AA	AA	A	4	1	0	2
	BBB			BBB	BBB	BB	BB5	B
Total	68	19	/	/	/	/	/	/	27	3	7	31

¹Number of rabbits with humane termination during Experiment 1;

²Number of rabbits left excluding rabbits with humane termination and failed liver stiffness measurement via ElastPQ during Experiment 1;

³Number of rabbits with humane termination during Experiment 2;

⁴Number of rabbits left excluding rabbits with humane termination, failed liver stiffness measurement via ElastPQ, and death during Experiment 2; A⁵ and B⁵ indicate rabbits with failed LSM via ElastPQ. POW: Postoperative weeks; LSM: Liver stiffness measurement; ElastPQ: Elastography point quantification; A: Rabbits receiving splenectomy and liver biopsy; B: Rabbits receiving only liver biopsy.