Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C

Figure 2 Hepatitis C virus entry is not impaired in APOB KO cells. A: Using an hepatitis C virus (HCV) genotype 1b pseudoparticle (HCVpp), cells were exposed to the pseudoparticle and incubated for 72 h at which time the degree of HCV entry was assessed using GFP expression; a control VZV pseudoparticle (VZVpp) was also assessed. We that entry of neither HCV nor VZV was impaired in the APOB KO cells; B: We confirmed that the expression levels of known HCV entry factors CD81, SRB1, CLDN1, OCLN1 were preserved in the KO cells (normalized to WT cell expression level, 1).