Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects

Figure 1 Reprogramming of glucose metabolism in hepatocellular carcinoma. Reprogramming of glucose metabolism-related enzymes and transporting proteins in HCC. The expression of GLUT1, GLUT2, HK2, HKDC1, GAPDH, PKM2, LDHA and MCT4 are up-regulated in HCC glycolysis pathway. GLUT: Glucose transporter; HK: Hexokinase; G6P: Glucose-6-phosphate; GPI1: Glucose-6-phosphate isomerase 1; F6P: Fructose-6-phosphate; PFK: Phosphofructokinase; FBP: Fructose-1,6-bisphosphatase; ALDA: Aldolase A, DHAP: Dihydroxyacetone phosphate; TIM: Triosephosphate isomerase; G3P: Glyceraldehyde-3-phosphate; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; PG: Phosphoglycerate; PGAM: Phosphoglycerate mutase; ENO: Enolase; PEP: Phosphoenolpyruvate; PKM2: Pyruvate kinase isoform M2; PFK: Phosphate fructose kinase; LDHA: Lactate dehydrogenase A; MCT4: Monocarboxylate transporter 4.