CYP1A1, CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms

Table 5 Interaction between CYP1A1*2A, CYP1A1*2C, CYP2E1*5B, CYP2E1*6, EPHX1 Tyr113His and EPHX1 His139Arg polymorphisms and tobacco or alcohol consumption on the risk of SCRC

	Tobacco consumption							Alcohol consumption
	Non-smoker			Smoker			P value	Non-drinker			Drinker			P value
	Control	Case	OR1 (95%CI)	Control	Case	OR1 (95%CI)		Control	Case	OR1 (95%CI)	Control	Case	OR1 (95%CI)
CYP1A1*2A
T/T	156	96	1	90	69	1.12 (0.69-1.83)	0.33	137	92	1	109	73	1.62 (0.97-2.70)	0.35
T/C-C/C	87	35	0.87 (0.51-1.49)	67	27	0.65 (0.35-1.21)		81	35	0.88 (0.50-1.52)	73	27	0.95 (0.50-1.81)
CYP1A1*2C
A/A	190	107	1	122	86	1.08 (0.68-1.69)	0.21	165	105	1	147	88	1.42 (0.89-2.29)	0.91
A/G-G/G	53	24	0.81 (0.43-1.52)	35	10	0.44 (0.18-1.06)		53	22	0.65 (0.34-1.25)	35	12	0.87 (0.38-2.00)
CYP2E1*5B
G/G	215	94	1	136	63	0.90 (0.56-1.44)	0.83	190	85	1	161	72	1.56 (0.96-2.53)	0.68
G/C-C/C	28	37	2.69 (1.41-5.10)	21	33	2.68 (1.33-5.41)		28	42	3.07 (1.63-5.80)	21	28	3.90 (1.82-8.38)
CYP2E1*6
T/T	189	72	1	125	54	0.96 (0.57-1.63)	0.87	171	70	1	143	56	1.47 (0.85-2.55)	0.78
T/A-A/C	54	59	2.89 (1.70-4.93)	32	42	2.99 (1.58-5.64)		47	57	3.14 (1.80-5.48)	39	44	4.10 (2.18-7.72)
EPHX1 Tyr113His
T/T	129	75	1	85	51	0.89 (0.51-1.54)	0.60	122	75	1	92	51	1.30 (0.74-2.31)	0.57
T/C-C/C	114	56	0.84 (0.51-1.40)	72	45	0.92 (0.52-1.62)		96	52	0.83 (0.49-1.41)	90	49	1.36 (0.78-2.37)
EPHX1 His139Arg
A/A	141	89	1	94	64	0.87 (0.52-1.44)	0.38	132	83	1	103	70	1.66 (0.98-2.80)	0.34
A/G-G/G	102	42	0.64 (0.38-1.09)	63	32	0.79 (0.44-1.44)		86	44	0.89 (0.52-1.53)	79	30	1.00 (0.54-1.85)

¹Odds Ratio (OR) adjusted for age, gender and tobacco or alcohol consumption.