CYP1A1, CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms

Table 4 Association of CYP1A1*2A, CYP1A1*2C, CYP2E1*5B, CYP2E1*6, EPHX1 Tyr113His and EPHX1 His139Arg polymorphisms with sporadic colorectal cancer

Models	Genotype	Control, n (%)	Case, n (%)	OR1 (95%CI)	P value	Genotype	Control, n (%)	Case, n (%)	OR1 (95%CI)	P value
	CYP1A1*2A					CYP1A1*2C
Codominant	T/T	246 (61.5)	165 (72.7)	1.00 (reference)		A/A	312 (78)	193 (85)	1.00 (reference)
	T/C	125 (31.3)	53 (23.3)	0.76 (0.49-1.18)	0.27	A/G	75 (18.8)	30 (13.2)	0.70 (0.41-1.20)	0.13
	C/C	29 (7.2)	09 (4)	0.59 (0.25-1.39)		G/G	13 (3.2)	4 (1.8)	0.36 (0.10-1.31)
Dominant	T/T	246 (61.5)	165 (72.7)	1.00 (reference)		A/A	312 (78)	193 (85)	1.00 (reference)
	T/C-C/C	154 (38.5)	62 (27.3)	0.73 (0.49-1.10)	0.13	A/G-G/G	88 (22)	34 (15)	0.64 (0.38-1.06)	0.08
Recessive	T/T-T/C	371 (92.8)	218 (96)	1.00 (reference)		A/A-T/G	387 (96.8)	223 (98.2)	1.00 (reference)
	C/C	29 (7.2)	09 (4)	0.64 (0.27-1.50)	0.29	G/G	13 (3.2)	4 (1.8)	0.38 (0.10-1.38)	0.12
Overdominant	T/T-C/C	275 (68.8)	174 (76.7)	1.00 (reference)		A/A-G/G	325 (81.2)	197 (86.8)	1.00 (reference)
	T/C	125 (31.2)	53 (23.3)	0.80 (0.52-1.23)	0.30	A/G	75 (18.8)	30 (13.2)	0.72 (0.42-1.24)	0.23
Log-additive	T/T	246 (61.5)	165 (72.7)	1.00 (reference)		A/A	312 (78)	193 (85)	1.00 (reference)
	T/C	125 (31.3)	53 (23.3)	0.77 (0.55-1.06)	0.11	A/G	75 (18.8)	30 (13.2)	0.66 (0.43-1.00)	0.05
	C/C	29 (7.2)	09 (4)			G/G	13 (3.2)	4 (1.8)
	CYP2E1*5B					CYP2E1*6
Codominant	G/G	351 (87.8)	157 (69.2)	1.00 (reference)		T/T	314 (78.5)	126 (55.5)	1.00 (reference)
	G/C	49 (12.2)	67 (29.5)	2.66 (1.64-4.32)	< 0.012	T/A	82 (20.5)	93 (41)	2.81 (1.84-4.28)	< 0.012
	C/C	0	03 (1.3)	-		A/A	04 (1)	8 (3.5)	7.32 (1.85-28.96)
Dominant	G/G	351 (87.8)	157 (69.2)	1.00 (reference)		T/T	314 (78.5)	126 (55.5)	1.00 (reference)
	G/C-C/C	49 (12.2)	70 (30.8)	2.82 (1.74-4.55)	< 0.002	T/A-A/A	86 (21.5)	101 (44.5)	2.97 (1.97-4.50)	< 0.012
Recessive	G/G-G/C	400 (100)	224 (98.7)	1.00 (reference)		T/T-T/A	396 (99)	219 (96.5)	1.00 (reference)
	C/C	0	03 (1.3)	-	-	A/A	4 (1)	8 (3.5)	5.26 (1.35-20.50)	0.0162
Overdominant	G/G-C/C	351 (87.8)	160 (70.5)	1.00 (reference)		T/T-A/A	318 (79.5)	134 (59)	1.00 (reference)
	G/C	49 (12.2)	67 (29.5)	2.58 (1.59-4.19)	< 0.012	T/A	82 (20.5)	93 (41)	2.64 (1.74-4.01)	< 0.012
Log-additive	G/G	351 (87.8)	157 (69.2)	1.00 (reference)		T/T	314 (78.5)	126 (55.5)	1.00 (reference)
	G/C	49 (12.2)	67 (29.5)	2.84 (1.78-4.52)	< 0.012	T/A	82 (20.5)	93 (41)	2.78 (1.91-4.06)	< 0.012
	C/C	0	03 (1.3)			A/A	4 (1)	8 (3.5)
	EPHX1 Tyr113His					EPHX1 His139Arg
Codominant	T/T	214 (53.5)	126 (55.5)	1.00 (reference)		A/A	235 (58.8)	153 (67.4)	1.00 (reference)
	T/C	158 (39.5)	88 (38.8)	0.95 (0.63-1.41)	0.84	A/G	145 (36.2)	67 (29.5)	0.79 (0.52-1.20)	0.18
	C/C	28 (7)	13 (5.7)	0.80 (0.36-1.76)		G/G	20 (5)	7 (3.1)	0.42 (0.14-1.26)
Dominant	T/T	214 (53.5)	126 (55.5)	1.00 (reference)		A/A	235 (58.8)	153 (67.4)	1.00 (reference)
	T/C-C/C	186 (46.5)	101 (44.5)	0.92 (0.63-1.36)	0.68	A/G-G/G	165 (41.2)	74 (32.6)	0.74 (0.50-1.11)	0.15
Recessive	T/T-T/C	372 (93)	214 (94.3)	1.00 (reference)		A/A-A/G	380 (95)	220 (96.9)	1.00 (reference)
	C/C	28 (7)	13 (5.7)	0.81 (0.37-1.77)	0.60	G/G	20 (5)	7 (3.1)	0.45 (0.15-1.35)	0.14
Overdominant	T/T-C/C	242 (60.5)	139 (61.2)	1.00 (reference)		A/A-G/G	255 (63.8)	160 (70.5)	1.00 (reference)
	T/C	158 (39.5)	88 (38.8)	0.97 (0.65-1.44)	0.88	A/G	145 (36.2)	67 (29.5)	0.83 (0.55-1.25)	0.37
Log-additive	T/T	214 (53.5)	126 (55.5)	1.00 (reference)		A/A	235 (58.8)	153 (67.4)	1.00 (reference)
	T/C	158 (39.5)	88 (38.8)	0.92 (0.67-1.25)	0.59	A/G	145 (36.2)	67 (29.5)	0.74 (0.52-1.04)	0.08
	C/C	28 (7)	13 (5.7)			G/G	20 (5)	7 (3.1)

¹Odds ratio (OR) adjusted for age, gender and tobacco and alcohol consumption and polymorphisms in the dominant model;

²Significant P values < 0.05.