Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects

doi:10.3748/wjg.v22.i45.9933

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2016; 22(45): 9933-9943
Published online Dec 7, 2016. doi: 10.3748/wjg.v22.i45.9933

Table 1 Oncogenes and tumor suppressor genes involved in glucose metabolic reprogramming during carcinogenesis

	Genes	Targets	Ref.
Oncogenes	HIF-1	HK1	[55]
		HK2	[55]
		GAPDH	[55]
		PKM	[55]
	Myc	LDHA	[58]
		GLUT1	[59]
		HK2	[60]
	CD147	MCT1	[62]
		GLUT1	[62]
	PIM1	GLUT1	[65]
		PKM2	[65]
Tumor suppressor	P53	GLUTs	[66]
genes	RRAD	GLUT1	[67,68]
genes	RRAD	HK2	[67]

GLUT: Glucose transporter; HK: Hexokinase; PKM: Pyruvate kinase isoform M; LDHA: Lactate dehydrogenase A; MCT1: Monocarboxylate transporter 1; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; RRAD: Ras-related associated with diabetes.

Citation: Shang RZ, Qu SB, Wang DS. Reprogramming of glucose metabolism in hepatocellular carcinoma: Progress and prospects. World J Gastroenterol 2016; 22(45): 9933-9943
URL: https://www.wjgnet.com/1007-9327/full/v22/i45/9933.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i45.9933