Therapeutic approaches for portal biliopathy: A systematic review

Table 4 Surgical management of portal biliopathy: summary of case series and case reports

Ref.	No. of patients	Biliary abnormalities	First treatment	Follow-up	Further treatments	Complications/outcome
Chaudhary et al[53], 1998	9 symptomatic	Stenosis: 2 CBD stones: 2	BA 2 SRS 7	9 pts -	BA 2 Stent 1 ES + SE 2	Death 1 Resolution 7
Condat et al[3], 2003	7 symptomatic	Cholecystitis/right hypocondrial pain 4 Cholangitis 1 Stenosis 2	Cholecystostomy + ERCP 1 Stent 1 BA+PTBD 1	4-25 mo	-	Haemobilia 1
Gauthier-Villars et al[19], 2005	8 symptomatic (pediatric)	Stenosis 6 Biliarydilation 8	- PSS 8	8 pts 4.5-15 yr	-	Complete resolution 7 Partial resolution 1
Khare et al[25], 2005	13 symptomatic	A: Stenosis 5 B: CBD stones 3 C: Stenosis + CBD stones 5	A: PSS 4; BA 1 B: ERCP 2; PSS + BA 1 C: Unsuccessful ERCP 4; PSS 3; Splenectomy + devasc 2	-	A: Multiple ERCP: 1 B: Splenectomy 1 (post-ERCP) C: Multiple ERCP 2; BA 1; Splenectomy + BA 1	Death 1
Vibert et al[30], 2007	19 symptomatic	IE biliary dilation 9 IE stones 7 CBD stones 4	PSS group: PTBD 1 SRS 10 NPSS group: ES + stent 2 ES + SE 1 PTBD 6 BA 4	19 pts 4-30 mo	PSS group: BA 5 NPSS group PTBD 1 after ERCP and 4 after BA	Resolution 17 Death 3
Dhiman et al[2], 2007	12 symptomatic	Stenosis: 7 CBD stones: 5 Choledochal varices 2 Mirizzi’ssyndrome 1	PSS 5 ES 3 ES + dilation 2 Stent 4	19 mo (range 6-132)	Multiple stent exchange in pts initially treated with stent	Cholangitis in 2 pts treated with stent
D’Souza et al[54], 2009	1 symptomatic	CBD stenosis + GB stones	Pre-surgery stent→PSS + BA (single stage)	18 mo	-	Resolution
Camerlo et al[51], 2010	3 symptomatic	Stenosis 3	PSS 3 Stent 1 (pre-PSS)	3 pts 2-13 yr	-	Resolution 3
Agarwal et al[55], 2011	39 symptomatic	Stenosis 15 CBD stones 7 GB stones 12 IE dilation 39	SRS 37 BA 2	37 pts 32 mo	ES ± SE 10 BA 12 ES + cholecystectomy 1	Resolution 35
Chattopadhyay et al[52], 2012	24 symptomatic 32 asymptomatic	CBD stenosis 3 Multiple stenosis 5 IE dilation 14 CBD stones 7 GB stones 11	ERCP pre-surgery 12 PSS 40 Splenectomy + devasc. 16	43 pts 48 mo (range 14-120)	ES + SE 2 Multiple ES + stent 5 BA 2	Resolution 38 Death 1
Suárez et al[56], 2013	3 symptomatic	Stenosis 3	UDCA 1 BA 1	-	-	-
Bhatia et al[57], 2014	2 symptomatic	GB stones	Cholecistectomy	-	-	Resolution
Liu et al[58], 2015	18	Stenosis 6 Dilations 6 Stenosis + dilations 6	PSS 18	-	-	Resolution 15

CBD: Common bile duct; GB: Gallbladder; IE: Intrahepatic; ES: Endoscopic sphincterotomy; SE: Stone extraction; BD: Balloon dilation; PSS: Porto-systemic shunt; NPSS: No porto-systemic shunt; UDCA: Ursodeoxycholic acid; ERCP: Endoscopic retrograde cholangio-pancreatography; BA: Bilioenteric anastomosis; SRS: Splenorenal shunt; FU: Follow-up.