Preoperative evaluation of pancreatic ductal adenocarcinoma with synchronous liver metastasis: Diagnosis and assessment of unresectability

Table 6 Cox regression analysis of prognostic factors in pancreatic ductal adenocarcinoma patients with synchronous liver metastasis undergoing surgery

Parameter	n	Median OS (95%CI) (mo)	Univariate analysis	Multivariate analysis
			P value	Hazard ratio	95%CI	P value
Age, yr
≤ 62	32	9.988 (5.215-14.760)
> 62	37	4.534 (3.294-5.774)	0.006	2.191	1.182-4.060	0.013
Sex
Male	47	5.388 (2.454-8.322)
Female	22	7.129 (5.820-8.439)	0.428
BMI, kg/m2
< 18	6	4.008 (0.000-8.701)	0.939
18-25	54	6.998 (5.147-8.849)
> 25	9	7.721 (1.548-13.894)	0.548
Smoke
No	50	7.031 (4.606-9.455)
Yes	19	5.979 (0.607-11.352)	0.317
ASA
I	21	9.988 (3.524-16.452)
II-III	48	6.998 (3.803-10.193)	0.273
Primary tumor location
Head/neck	53	6.998 (4.910-9.086)
Body/tail	16	7.129 (3.438-10.820)	0.762
CA19-9, U/mL
≤ 400	40	7.984 (6.454-9.513)
> 400	29	4.008 (2.832-5.185)	0.042	1.398	0.773-2.527	0.267
CA125, U/mL
≤ 62	32	9.035 (7.052-11.017)
> 62	37	4.008 (2.801-5.215)	0.003	2.601	1.403-4.823	0.002
CEA, U/mL
≤ 5	42	7.721 (6.340-9.102)
> 5	27	5.191 (1.847-8.535)	0.320
Fibrinogen, g/L
≤ 4.0	50	7.129 (5.373-8.886)
> 4.0	19	5.191 (2.575-7.807)	0.533
NLR
≤ 5	59	7.031 (5.123-8.939)
> 5	10	4.008 (0.000-9.812)	0.495
PLR
≤ 150	36	7.031 (4.545-9.517)
> 150	33	5.979 (3.287-8.672)	0.851
PNI
> 45	42	7.129 (6.237-8.022)
≤ 45	27	5.848 (3.396-8.300)	0.890
Platelet
≤ 250 × 109/L	53	6.998 (5.018-8.978)
> 250 × 109/L	16	7.097 (0.957-13.236)	0.993
Jaundice
No	34	7.721 (4.540-10.901)
Yes	35	6.998 (3.593-10.403)	0.446
Biliary drainage
No	45	7.129 (5.245-9.014)
Yes	24	5.027 (1.872-8.181)	0.878
Bilirubin, μmol/L
≤ 50	58	6.998 (4.918-9.078)
> 50	11	7.031 (1.408-12.651)	0.448
Albumin, g/L
> 35	42	7.097 (4.893-9.300)
≤ 35	27	5.027 (2.171-7.882)	0.799
Diabetes mellitus
No	39	6.998 (4.177-9.819)
Yes	30	6.998 (4.424-9.572)	0.300
Pancreatitis
No	42	5.979 (4.876-9.186)
Yes	27	6.998 (2.516-11.480)	0.789