Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population

Figure 4 Receiver operating characteristic curve of miR-34a, alanine aminotransferase, cytokeratin-18, fibrosis-4 and aspartate aminotransferase to platelet ratio index for on-alcoholic steatohepatitis (A) and miR-16, fibrosis-4 and aspartate aminotransferase to platelet ratio index for significant fibrosis (B) diagnosis in non-alcoholic fatty liver disease. The AUROC of miR-34a and miR-16 for non-alcoholic steatohepatitis (NASH) and significant fibrosis were 0.811 and 0.716, respectively. Circulating miR-34a significantly increased the sensitivity to 0.704, with a comparable specificity. For the diagnosis of significant fibrosis, miR-16 displayed a relatively lower AUROC than that of FIB-4 and APRI. ALT: Alanine aminotransferase; CK-18: Cytokeratin-18; FIB-4: Fibrosis-4; APRI: Aspartate aminotransferase to platelet ratio index.