Naringenin protects against isoniazid- and rifampicin-induced apoptosis in hepatic injury

Figure 1 Naringenin pretreatment protects mice from isoniazid- and rifampicin-induced liver injury. A: Levels of serum transaminases were analyzed; B: Liver indexes were measured. All data are expressed as means ± SEM for ten samples per group. ^bP < 0.01 vs control group, ^cP < 0.05 vs INH and RIF group, ^dP < 0.01 vs INH and RIF group; C: Liver section from mice treated with NSS; D: Liver section from mice treated with INH and RIF; E and F: Liver sections from mice pretreated with NRG (50 or 100 mg/kg) before INH and RIF challenge. Liver sections were stained with hematoxylin and eosin (original magnification: × 400). NRG: Naringenin; INH: Isoniazid; RIF: Rifampicin.