Galectin-3 and IL-33/ST2 axis roles and interplay in diet-induced steatohepatitis

Figure 3 Galectin-3 and IL-33/ST2 axis interaction in diet-induced steatohepatitis. Administration of IL-33 in vivo enhanced high-fat diet-induced liver fibrosis in both genotypes of mice, although to a markedly lower extent in the galectin-3 knockout mice, which was accompanied by less numerous ST2-positive myeloid cells that express IL-13. Galectin-3 plays an important regulatory role in the newly described profibrotic IL-33/ST2/IL-13 pathway in hepatic fibrosis.