Galectin-3 and IL-33/ST2 axis roles and interplay in diet-induced steatohepatitis

Figure 2 Galectin-3 and IL-33/ST2 axis in diet-induced steatohepatitis. Increased liver steatosis, but attenuated inflammation and fibrosis, in Galectin-3 knockout mice fed high-fat diet compared to diet matched C57Bl/6 wild-type mice (left panel). Decreased liver steatosis, inflammation and fibrosis in ST2 knockout mice fed high-fat diet compared to diet matched BALB/c wild-type mice.