Prognostic implications of FGFR1 and MYC status in esophageal squamous cell carcinoma

Table 4 Multivariate analysis for overall survival in patients with esophageal squamous cell carcinoma

Variables	Category	Whole cohort		No adjuvant chemo- and/or radiotherapy		Adjuvant chemo- and/or radiotherapy
		HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Age (yr)	≤ 60 vs > 60	1.805 (1.102-2.955)	0.019	2.371 (1.088- 5.167)	0.030	1.81 (0.896-3.656)	0.098
T	1, 2, 3, 4	-	0.005	-	0.091	-	0.009
	1 vs 2	1.204 (0.523-2.773)	0.663	1.589 (0.591-4.269)	0.358	1.260 (0.251-6.324)	0.779
	1 vs 3	2.373 (1.454-3.872)	0.001	2.115 (1.126-3.973)	0.020	4.136 (1.691-10.119)	0.002
	1 vs 4	1.902 (0.550-6.575)	0.310	0.632 (0.078-5.130)	0.667	4.256 (0.820-22.092)	0.085
N	0 vs 1-3	1.981 (1.275-3.077)	0.002	2.351 (1.338-4.133)	0.003	0.319 (0.125-0.814)	0.017
FGFR1 amplification	None vs Amplification	0.532 (0.302-0.937)	0.029	0.301 (0.117-0.774)	0.013	0.830 (0.386-1.783)	0.633
MYC expression	None vs Expression	0.993 (0.636-1.550)	0.975	0.873 (0.478-1.595)	0.659	1.566 (0.811-3.024)	0.181