Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C

Table 3 Accuracy of angiopoietins to discriminate significant fibrosis (F > 1), advanced fibrosis (F > 2) and cirrhosis (F > 3) in chronic hepatitis C patients

	AUC-ROC (95%CI)	Criterion	Se	95%CI	Sp	95%CI	+LR	95% CI	-LR	95%CI	+PV	95%CI	-PV	95%CI	Cost	ACC
F > 1
Ang1	0.650 (0.575 -0.720)	≤ 54337.63	60.58%	51.9-68.8	69.05%	52.9-82.4	1.96	1.2-3.1	0.57	0.4-0.8	64.40	52.9-74.7	65.5	55.2-74.8	0.35	65.00%
Ang2	0.664 (0.589-0.732)	> 4041.67	49.64%	41.0-58.3	83.33%	68.6-93.0	2.98	1.5-6.0	0.60	0.5-0.7	73.30	60.1-84.1	64.2	55.0-72.7	0.33	67.20%
Ang2/ Ang1	0.724 (0.652- 0.788)	> 7.162	57.66%	48.9-66.1	78.57%	63.2-89.7	2.69	1.5-4.9	0.54	0.4-0.7	71.30	59.2-81.5	66.8	57.1-75.5	0.32	68.50%
F > 2
Ang1	0.635 (0.560-0.705)	≤ 47573.25	49.3%	37.2-61.4	75.93%	66.7-83.6	2.05	1.4-3.1	0.67	0.5-0.9	41.80	28.7-55.9	81.0	73.0-87.5	0.31	69.00%
Ang2	0.712 (0.639-0.777)	> 4256	60.56%	48.3-72.0	76.85%	67.8-84.4	2.62	1.8-3.9	0.51	0.4-0.7	47.90	34.7-61.3	84.7	77.0-90.6	0.27	72.60%
Ang2/ Ang1	0.740 (0.669-0.802)	> 9.262	56.34%	44.0-68.1	85.19%	77.1-91.3	3.80	2.3-6.2	0.51	0.4-0.7	57.20	41.7-71.7	84.7	77.5-90.4	0.22	77.70%
F > 3
Ang1	0.734 (0.663-0.797)	≤ 47573.25	70.97%	52.0-85.8	73.65%	65.8-80.5	2.69	1.9-3.8	0.39	0.2-0.7	37.90	25.9-51.2	91.8	85.3-96.1	0.27	73.20%
Ang2	0.761 (0.691-0.821)	> 4256	74.19%	55.4-88.1	69.59%	61.5-76.9	2.44	1.8-3.4	0.37	0.2-0.7	35.60	24.5-48.1	92.2	85.6-96.5	0.30	70.40%
Ang2/ Ang1	0.810 (0.744- 0.864)	> 10.33	70.97%	52.0-85.8	84.46%	77.6-89.9	4.57	2.9-7.1	0.34	0.2-0.6	50.90	35.8-65.9	92.8	87.0-96.5	0.18	82.00%

Youden index criterion. AUC-ROC: Area under the curve of receiver operator characteristics; Se: Sensitivity; Sp: Specificity; +LR: Positive Likelihood ratio; -LR: Negative Likelihood ratio; +PV: Positive predictive value; -PV: Negative predictive value; ACC: Accuracy, n = 179 chronic hepatitis C; Ang1: Angiopoietin 1; Ang2: Angiopoietin 2.