Galectin-3 and IL-33/ST2 axis roles and interplay in diet-induced steatohepatitis

doi:10.3748/wjg.v22.i44.9706

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2016; 22(44): 9706-9717
Published online Nov 28, 2016. doi: 10.3748/wjg.v22.i44.9706

Table 1 Changes in mRNA levels of lipid metabolism and fibrosis-related genes in livers of LGALS3^-/- and ST2^-/- mice during high-fat diet-induced nonalcoholic steatohepatitis

Target gene	LGALS3^-/- mice	ST2^-/- mice
Abca-1	Upregulated	Unchanged
Cd36	Upregulated	Downregulated
LXR-α	Unchanged	Downregulated
PPARγ	Upregulated	Downregulated
Coll-α1	Downregulated	Downregulated
α-SMA	Downregulated	Unchanged
IL-33	Downregulated	Downregulated
IL-13	Downregulated	Downregulated
TGF-β	Unchanged	Unchanged

Abca-1: ATP-binding cassette transporter; LXR-α: Liver X receptor-alpha; PPARγ: Peroxisome proliferator-activated receptor gamma; Coll-α1: Procollagen alpha 1; α-SMA: Alpha-smooth muscle actin; IL-33: Interleukin-33; IL-13: Interleukin-13; TGF-β: Transforming growth factor-beta.

Citation: Pejnovic N, Jeftic I, Jovicic N, Arsenijevic N, Lukic ML. Galectin-3 and IL-33/ST2 axis roles and interplay in diet-induced steatohepatitis. World J Gastroenterol 2016; 22(44): 9706-9717
URL: https://www.wjgnet.com/1007-9327/full/v22/i44/9706.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i44.9706