Hepatitis B virus upregulates host expression of α-1,2-mannosidases via the PPARα pathway

Figure 4 MK886 can neutralize the effects of hepatitis B virus. MK886 neutralizes the effects of HBV on MAN1C1 (A) Western blot indicating that the MAN1C1 expression significantly increased in HepG2 cells transfected with PTT22-HBs in the presence of GW9662 but not MK886. B: Quantification of MAN1C1 expression from the band intensities normalized by ACTIN. C: Western blot showed that after the addition of MK886, the expression of MAN1C1 did not alter in HepAD38 cells without Tet as compared to that in the HepAD38 cells with Tet. Moreover, there was no effect of GW9662 on the expression of MAN1C1 in AD38 cells with or without Tet treatment. D: Quantification of the α-1,2-mannosidases expression from the band intensities normalized by ACTIN. The data shown represent the mean ± SD of three independent experiments, ^aP < 0.05.