Anti-inflammatory effect of cannabinoid agonist WIN55, 212 on mouse experimental colitis is related to inhibition of p38MAPK

Figure 2 Histopathological score of dextran sulfate sodium-induced colitis in C57BL/6 mice. A: Control; B: Dextran sulfate sodium (DSS) + vehicle (Veh); C: DSS + SB203580 (SB); D: DSS + WIN (WIN55). Arrows marked in the figure (HE-staining, magnification × 100, respectively) point to the damage in epithelium, or edema in the sub-mucosa, or infiltration of inflammatory cells; E: Histopathological score (HS) was calculated as described in the Materials and Methods. Data of HS are presented as mean ± SEM (n = 8). ^aP < 0.05 vs control; ^cP < 0.05 vs DSS + Veh.