Anti-inflammatory effect of cannabinoid agonist WIN55, 212 on mouse experimental colitis is related to inhibition of p38MAPK

Figure 1 Macroscopical score of dextran sulfate sodium-induced colitis in C57BL/6 mice (A-D). Macroscopical score (MS) of was calculated as described in the Materials and Methods. SB203580 (5 μmol/kg) was injected i.p. twice daily beginning from 60 h after dextran sulfate sodium (DSS) treatment inception and continuing until the last day. WIN55 (5 mg/kg) was administered i.p., once daily for 7 consecutive days, starting from DSS treatment until the end of the experiment. Data of macroscopical parameters are presented as mean ± SEM (n = 8). ^aP < 0.05 vs control; ^cP < 0.05 vs DSS + vehicle (Veh). SB: SB203580; WIN: WIN55.