Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux

Table 5 Sensitivity, specificity, positive and negative predictive values of diagnostic tests according to assumed gold standard test

Test	Gold standard
	MII-pH monitoring				GES
	Sensitivity, %	Specificity, %	PPV, %	NPV, %	Sensitivity, %	Specificity, %	PPV, %	NPV, %
	(95%CI)	(95%CI)	(95%CI)	(95%CI)	(95%CI)	(95%CI)	(95%CI)	(95%CI)
MII-pHM	-	-	-	-	87.2	23.1	80.4	33.3
					(73.6-94.7)	(6.2-54.0)	(66.5-89.7)	(9.0-69.1)
pHM alone	66.7	100	100	34.6	53.2	30.8	73.5	15.4
	(52.0-78.9)	(62.9-100.0)	(87.4-100.0)	(17.9-55.6)	(38.2-67.6)	(10.4-61.1)	(55.3-86.5)	(5.0-35.7)
MII alone	73.3	100	100	56.3	72.3	23.1	77.3	18.6
	(73.1-93.8)	(62.9-100.0)	(90.0-100.0)	(30.6-79.2)	(57.1-83.9)	(6.0-54.0)	(61.8-88.0)	(5.0-46.3)
GES	80.4	33.3	87.2	23.1	-	-	-	-
	(66.5-89.7)	(9.0-69.1)	(73.6-94.7)	(6.1-54.0)

GES: Gastroesophageal scintigraphy; MII-pHM: Multichannel intraluminal impedance-pH monitoring; pHM: Esophageal pH monitoring; MII: Multichannel intraluminal impedance monitoring; PPV: Positive predictive value; NPV: Negative predictive value.