Ceruloplasmin, a reliable marker of fibrosis in chronic hepatitis B virus patients with normal or minimally raised alanine aminotransferase

Table 6 Validity of APRI, FIB-4, PPT, and APPCI models for prediction of minimal fibrosis (F0-F1), and comparison with the CG model (n = 193)

Model	AUC (95%CI)	Youden’s index	Sensitivity	Specificity	PPV	NPV	Z value	P value
CG	0.789 (0.727-0.852)	0.486	80.26%	68.38%	62.25%	84.21%	-	-
FIB-4	0.671 (0.595-0.747)	0.271	72.37%	54.69%	50.92%	75.29%	2.339	0.0191
APRI	0.736 (0.666-0.805)	0.354	78.95%	56.42%	54.06%	80.49%	1.100	0.271
PPT	0.741 (0.672-0.810)	0.380	64.47%	73.51%	61.26%	76.10%	1.012	0.312
APPCI	0.818 (0.760-0.877)	0.544	89.47%	64.96%	62.39%	90.47%	-0.661	0.509
GP	0.675 (0.601-0.749)	0.325	82.89%	49.58%	51.64%	81.69%	2.295	0.0221

¹Indicates significant differences compared with the CG model. AUC: Area under the receiver operating characteristic curve; NPV: Negative predictive value; PPV: Positive predictive value.