Ceruloplasmin, a reliable marker of fibrosis in chronic hepatitis B virus patients with normal or minimally raised alanine aminotransferase

Table 5 Validity of APRI, FIB-4, PPT, and APPCI models for prediction of cirrhosis, and comparison with the CG model (n = 193)

Model	AUC (95%CI)	Youden’s index	Sensitivity	Specificity	PPV	NPV	Z value	P value
CG	0.812 (0.740-0.883)	0.567	72.84%	83.88%	46.37%	94.17%	-	-
FIB-4	0.679 (0.581-0.777)	0.318	52.23%	80.65%	34.06%	89.82%	2.138	0.0331
APRI	0.775 (0.698-0.852)	0.416	64.20%	77.43%	34.52%	91.46%	0.688	0.491
PPT	0.777 (0.671-0.883)	0.512	80.25%	70.97%	34.59%	94.94%	0.535	0.593
APPCI	0.859 (0.789-0.929)	0.592	75.31%	83.89%	47.21%	94.67%	-0.910	0.363
GP	0.742 (0.647-0.838)	0.420	70.99%	70.97%	31.87%	92.75%	1.140	0.254

¹Indicates significant differences compared with the CG model. AUC: Area under the receiver operating characteristic curve; NPV: Negative predictive value; PPV: Positive predictive value.