Ceruloplasmin, a reliable marker of fibrosis in chronic hepatitis B virus patients with normal or minimally raised alanine aminotransferase

Table 2 Serum ceruloplasmin levels distinguish different stages of fibrosis as measured by area under the curve values (n = 97)

Fibrosis stages	AUC (95%CI)	Cut-off point	Sensitivity	Specificity	PPV	NPV
F ≥ 2	0.776 (0.711-0.841)	≤ 194	86.84%	58.98%	28.83%	95.91%
F = 4	0.767 (0.691-0.843)	≤ 186	54.32%	90.33%	51.80%	91.18%

AUC: Area under the receiver operator characteristic curve; NPV: Negative predictive value; PPV: Positive predictive value.