Ceruloplasmin, a reliable marker of fibrosis in chronic hepatitis B virus patients with normal or minimally raised alanine aminotransferase

Table 1 Demographic, biological, and histological features for the training and validation groups

Variable	All (n = 193)	Training group (n = 97)	Validation group (n = 96)	P value
Age, in yr	39.11 ± 9.31	38.70 ± 9.46	39.52 ± 9.18	0.542
Sex, n (%)				0.601
Male	138 (71.5)	71 (73.2)	67 (69.8)
Female	55 (28.5)	26 (26.8)	29 (30.2)
Total bilirubin, in μmol/L	12.3 (8.7-18.2)	11.4 (8.6-16.9)	12.9 (8.8-18.8)	0.352
Albumin, in g/L	42.21 ± 4.16	42.46 ± 3.91	41.94 ± 4.41	0.387
Globulin, in g/L	27.25 ± 4.36	27.54 ± 4.84	26.95 ± 3.81	0.345
ALT, in IU/L	37 (27-51)	35 (26.0-48.5)	38.5 (28-52)	0.378
AST, in IU/L	30 (25.0-37.5)	30 (26-38)	29 (25-37)	0.806
GGT, in IU/L	27 (18.0-40.5)	25 (18-38)	27 (19-43)	0.577
TBA, in mmol/L	5.9 (3.85-12.05)	6.5 (4.10-15.25)	5.45 (3.73-9.83)	0.146
ALP, in IU/L	69 (57.5-82.5)	69 (58.0-83.5)	68.5 (57.0-81.8)	0.990
CHE, in IU/L	8407.62 ± 2722.19	8393.56 ± 2423.51	8421.83 ± 3006.82	0.943
AFP, in ng/mL	3.25 (2.19-6.32)	3.30 (2.30-6.70)	3.20 (2.03-5.08)	0.377
PT, in s	12.4 (11.9-13.1)	12.4 (11.95-13.15)	12.3 (11.80-12.97)	0.061
INR	1.03 (0.98-1.09)	1.03 (0.99-1.10)	1.03 (0.98-1.08)	0.553
HBsAg levels, in log IU/mL	3.49 (3.12-3.97)	3.46 (3.08-3.90)	3.52 (3.16-4.03)	0.501
HBV DNA levels, in logIU/mL	5.27 ± 1.70	5.30 ± 1.67	5.24 ± 1.74	0.791
WBC, in 109/L	5.63 ± 1.49	5.66 ± 1.54	5.59 ± 1.44	0.723
PLT, in 109/L	179 (144.5-214.5)	179 (153.5-214.5)	177 (128.0-214.8)	0.208
CP, in mg/L	195.67 ± 35.62	196.86 ± 35.45	196.86 ± 35.45	0.643
Stage of fibrosis, n (%)				0.164
F1	76 (39.38)	42 (43.30)	34 (35.42)
F2	44 (22.80)	23 (23.71)	21 (21.88)
F3	42 (21.76)	18 (18.56)	24 (25.00)
F4	31 (16.06)	14 (14.43)	17 (17.70)

AFP: α-fetoprotein; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CHE: Cholinesterase; CP: Ceruloplasmin; GGT: Gamma glutamyl transpeptidase; HBV: Hepatitis B virus; PLT: Platelet count; PT: Prothrombin time; TBA: Total bile acid; WBC: White blood cell count.