Diabetes mellitus may affect the long-term survival of hepatitis B virus-related hepatocellular carcinoma patients after liver transplantation

Table 5 Multivariate proportional hazard model for overall survival after liver transplantation in 1631 patients with hepatitis B virus-related hepatocellular carcinoma

Variables	B	SE	Wald	P value	OR (95%CI)
Venous invasion, absent vs present	0.893	0.117	57.882	0.000	2.442 (1.940-3.074)
Pre-LT antitumor therapy			7.129	0.032
Local therapy	-0.319	0.138	5.368	0.021	1.375 (1.050-1.801)
Resection	-0.227	0.212	1.146	0.284	0.797 (0.526-1.208)
Age, ≤ 50 vs > 50	-0.248	0.104	5.655	0.017	0.781 (0.636-0.957)
ALP, ≤ 112 IU/L vs > 112 IU/L	-0.264	0.111	5.630	0.018	0.768 (0.618-0.955)
GGT, ≤ 54 IU/L vs > 54 IU/L	0.332	0.128	6.681	0.010	1.394 (1.084-1.793)
ALT			13.416	0.001
≤ 40 IU/L vs 40-80 IU/L	0.340	0.123	7.575	0.006	1.404 (1.103-1.789)
≤ 40 IU/L vs > 80 IU/L	0.496	0.141	12.396	0.000	1.642 (1.246-2.164)
Serum AFP level, in ng/mL			30.829	0.000
< 200 vs 200-400	0.525	0.185	8.097	0.004	1.691 (1.178-2.427)
< 200 vs 400-1000	0.399	0.163	6.012	0.014	1.491 (1.083-2.052)
< 200 vs 1000-2000	0.621	0.189	10.804	0.001	1.860 (1.285-2.693)
< 200 vs > 2000	0.725	0.160	20.569	0.000	2.065 (1.509-2.825)
Number of tumor nodules			47.936	0.000
Single vs 2-3	0.528	0.138	14.631	0.000	1.695 (1.293-2.221)
Single vs≥ 4	0.851	0.124	47.265	0.000	2.342 (1.837-2.984)
Tumor size, in cm			78.643	0.000
≤ 3 vs 3-5	0.152	0.132	1.314	0.252	1.164 (0.898-1.509)
≤ 3 vs 5-7	0.739	0.149	24.596	0.000	2.093 (1.563-2.802)
≤ 3 vs > 7	1.252	0.152	67.571	0.000	3.496 (2.594-4.711)
DM, yes vs no	0.464	0.128	13.230	0.000	1.591 (1.239-2.043)

LT: Liver transplantation; GGT: Gamma-glutamyl transpeptidase; AFP: α-fetoprotein; DM: Diabetes mellitus; ALT: Alanine aminotransferase.