Increased CD4+CD45RA-FoxP3low cells alter the balance between Treg and Th17 cells in colitis mice

Figure 3 Treg cell subset characteristics in healthy control mice and ulcerative colitis mice peripheral blood monocytes, spleen, mesenteric lymph node, lamina propria of jejunum, and colon samples. A: FACS analysis of Treg cell subsets in HC and UC samples gated for CD4⁺ T cells; B: FoxP3 mRNA expression by FrIII cells from different HC and UC samples; C: Expression levels of IL-17A mRNA by FrIII cells in HC and UC samples; D: RORC mRNA expression by FrIII cells from HC and UC samples; E: Treg cell subset distribution in UC samples. ^aP < 0.05 vs control, ^bP < 0.01 vs control, ^cP < 0.001 vs control, ^dP < 0.05 vs LPC, ^eP < 0.01 vs LPC, ^fP < 0.001 vs LPC. PBMC: Peripheral blood monocytes; MLN: Mesenteric lymph node; FrI cells: CD4⁺CD45RA⁺FoxP3^low; FrII cells: CD4⁺CD45RA^-FoxP3^high; FrIII cells: CD4⁺CD45RA^-FoxP3^low; HC: Healthy control mice; UC: Ulcerative colitis mice; LPJ: Lamina propria of jejunum; LPC: Lamina propria of colon.