Increased CD4+CD45RA-FoxP3low cells alter the balance between Treg and Th17 cells in colitis mice

Figure 2 T helper 17 cell characteristics in healthy control mice and ulcerative colitis mice peripheral blood monocytes, spleen, mesenteric lymph node, lamina propria of jejunum and colon samples. A: FACS analysis of Th17 cells in HC and UC samples gated for CD4⁺ T cells; B: Percentages of Th17 cells in different HC and UC samples; C: Levels of IL-17A secreted by mononuclear cells extracted from HC and UC peripheral blood monocytes (PBMC), mesenteric lymph node (MLN), LPJ, and LPC samples; D: Treg cell distribution in HC and UC samples. ^aP < 0.05 vs control, ^bP < 0.01 vs control, ^cP < 0.001 vs control, ^dP < 0.05 vs LPC, ^eP < 0.01 vs LPC, ^fP < 0.001 vs LPC, ^gP < 0.001 vs LPJ. HC: Healthy control mice; UC: Ulcerative colitis mice; LPJ: Lamina propria of jejunum; LPC: Lamina propria of colon.