Increased CD4+CD45RA-FoxP3low cells alter the balance between Treg and Th17 cells in colitis mice

Figure 1 Treg cell features in multiple samples including peripheral blood monocytes, spleen, mesenteric lymph node, lamina propria of jejunum and colon. A: Representative FACS analysis of Treg cells from HC and UC mice samples gated for CD4⁺ T cells; B: Treg cell percentages in HC and UC samples; C: Expression of FoxP3 mRNA extracted from Treg cells in HC and UC samples; D: Levels of IL-10 secreted from mononuclear cells from HC and UC peripheral blood monocytes (PBMC), spleen, mesenteric lymph node (MLN), LPJ, and LPC samples; E: Treg cell distribution in HC and UC samples. ^aP < 0.05 vs control, ^bP < 0.01 vs control, ^cP < 0.001 vs control, ^dP < 0.05 vs LPC, ^eP < 0.01 vs LPC, ^fP < 0.001 vs LPC. HC: Healthy control mice; UC: Ulcerative colitis mice; LPJ: Lamina propria of jejunum; LPC: Lamina propria of colon.