Occult hepatitis B virus infection is not associated with disease progression of chronic hepatitis C virus infection

Table 4 Clinical factors associated with development of hepatocellular carcinoma

Variable	HR	P value	Adjusted HR	P value
OBI	0.904 (0.251-3.264)	0.878	0.860 (0.209-3.535)	0.835
Age (per year)	1.016 (0.962-1.073)	0.571
Male sex	1.531 (0.536-4.374)	0.427
AST > 40 IU/L	6.120 (1.351-27.729)	0.019	3.383 (0.664-17.226)	0.142
ALT > 40 IU/L	3.573 (0.976-13.075)	0.054
Creatinine (per unit)	0.051 (0.003-0.892)	0.042	0.075 (0.003-2.200)	0.133
AFP > 20 ng/mL	3.381 (1.129-10.121)	0.029	1.706 (0.512-5.678)	0.384
PT-INR (per unit)	10.081 (1.036-77.802)	0.027
Child-Pugh score	3.065 (1.741-5.399)	< 0.001	2.818 (1.547-5.135)	0.001
(per unit)
MELD score	1.057 (0.862-1.296)	0.597
(per unit)
SVR	0.289 (0.064-1.302)	0.106
HCV genotype 1	2.049 (0.644-6.517)	0.224

HR: Hazard ratio; OBI: Occult hepatitis B virus infection; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; AFP: Alpha-fetoprotein; PT-INR: Prothrombin time-international normalized ratio; MELD: Model for end-stage liver disease; SVR: Sustained virologic response; HCV: Hepatitis C virus.