Genetic polymorphism in CD14 gene, a co-receptor of TLR4 associated with non-alcoholic fatty liver disease

Table 3 Anthropometric and biochemical characteristics of patients with non-alcoholic fatty liver disease and healthy volunteers n (%)

Parameters	NAFLD (n = 200)	HVs (n = 50)	P value
Mean age (yr)	38.27 ± 10.3	36.56 ± 4.2	0.218
Gender	122 M/78 F	38 M/12 F
Mean BMI (kg/m2)	27.16 ± 4.7	22.1 ± 1.2	0.0002
Lean	35 (17.5)	46 (92)	0.0001
Overweight	39 (19.5)	3 (6)	0.02
Class I obesity	87 (43.5)	1 (2)	0.0001
Class II obesity	39 (19.5)	0 (0)	0.003
Waist (cm)	91.20 ± 9.5	78.12 ± 4.6	0.0001
Hip (cm)	91.32 (89.90-93.94)	89.18 (86.18-93.98)	0.3
Waist/hip ratio	0.99 (0.98-1.01)	0.93 (0.89-0.97)	0.016
Central obesity	135 (67.5)	0 (0)	0.0001
Mean AST (IU/L)	60.27 (46.0-78.7)	22.9 (18.75-29.50)	0.0001
Mean ALT (IU/L)	88.04 (68.9-118.9)	24 (17-29.5)	0.0001
Mean fasting sugar (mg/dL)	94.95 (87-105.8)	83.50 (75-89.25)	0.0001
Diabetes mellitus	29 (14.5)	0 (0)	0.005
Mean HDL (mg/dL)	43 (38-48.9)	52 (47.5-56)	0.0001
Mean Triglyceride (mg/dL)	156 (126-200.2)	102 (93-127.5)	0.0001
Hypertension	48 (24)	0 (0)	0.0001

NAFLD: Non-alcoholic fatty liver disease; HVs: Healthy volunteers; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; HDL: High-density lipoprotein.