Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases

doi:10.3748/wjg.v22.i42.9300

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2016; 22(42): 9300-9313
Published online Nov 14, 2016. doi: 10.3748/wjg.v22.i42.9300

Table 2 Comparison of avidity to tumor necrosis factor by anti-tumor necrosis factor agents

Target	Method/source	Avidity	Ref.
sTNF	KinExA^®	ETA > ADA	[41]
sTNF	(automated flow immunoassay system)	IFX	[41]
mTNF	[44]	IFX > ETA	[44]

ADA: Adalimumab; ETA: Etanercept; IFX: Infliximab; TNF: Tumor necrosis factor; mTNF: Membrane-bound TNF; sTNF: Soluble TNF.

Citation: Billmeier U, Dieterich W, Neurath MF, Atreya R. Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases. World J Gastroenterol 2016; 22(42): 9300-9313
URL: https://www.wjgnet.com/1007-9327/full/v22/i42/9300.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i42.9300