Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases

doi:10.3748/wjg.v22.i42.9300

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 22, Issue 42

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (28972)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-4) series.

Item

Count

PDF

2002

WORD

412

HTML

23360

Figures (1-2)

390

Tables (1-4)

256

Sum=26420

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1095

Download

1457

Sum=2552

Nov 14, 2016 (publication date) through Nov 23, 2024

Times Cited of This Article

Times Cited (165)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastroenterol. Nov 14, 2016; 22(42): 9300-9313
Published online Nov 14, 2016. doi: 10.3748/wjg.v22.i42.9300

Table 1 Comparison of affinity to tumor necrosis factor by anti-tumor necrosis factor agents

Target	Method /source	Affinity	Ref.
sTNF	SPR	GOL = ETA > IFX > ADA	[40]
sTNF	SPR	ETA > ADA = IFX	[41]
mTNF	mTNF-expressing cells (Sp2/0-11A5-1 myeloma cells)	IFX = ADA = ETA	[41]
mTNF	mTNF-expressing cells (K2 murine myeloma cells)	IFX = GOL > ADA > ETA	[40]
mTNF	PBMCs (T cells)	IFX = ADA > Certo >> No binding of ETA	[42]
mTNF	Flow cytometry	IFX = ADA > Certo >> No binding of ETA	[42]
mTNF	PBL	IFX >> No binding of ETA	[43]
mTNF	Flow cytometry	IFX >> No binding of ETA	[43]
sTNF	Immunoassay	IFX > ETA (rapid dissociation)	[44]

ADA: Adalimumab; ETA: Etanercept; GOL: Golimumab; IFX: Infliximab; Certo: Certolizumab pegol; PBL: peripheral blood lymphocytes; TNF: Tumor necrosis factor; mTNF: Membrane-bound TNF; sTNF: Soluble TNF; SPR: Surface plasmon resonance.

Citation: Billmeier U, Dieterich W, Neurath MF, Atreya R. Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases. World J Gastroenterol 2016; 22(42): 9300-9313
URL: https://www.wjgnet.com/1007-9327/full/v22/i42/9300.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i42.9300