Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases

doi:10.3748/wjg.v22.i42.9300

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2016; 22(42): 9300-9313
Published online Nov 14, 2016. doi: 10.3748/wjg.v22.i42.9300

Table 1 Comparison of affinity to tumor necrosis factor by anti-tumor necrosis factor agents

Target	Method /source	Affinity	Ref.
sTNF	SPR	GOL = ETA > IFX > ADA	[40]
sTNF	SPR	ETA > ADA = IFX	[41]
mTNF	mTNF-expressing cells (Sp2/0-11A5-1 myeloma cells)	IFX = ADA = ETA	[41]
mTNF	mTNF-expressing cells (K2 murine myeloma cells)	IFX = GOL > ADA > ETA	[40]
mTNF	PBMCs (T cells)	IFX = ADA > Certo >> No binding of ETA	[42]
mTNF	Flow cytometry	IFX = ADA > Certo >> No binding of ETA	[42]
mTNF	PBL	IFX >> No binding of ETA	[43]
mTNF	Flow cytometry	IFX >> No binding of ETA	[43]
sTNF	Immunoassay	IFX > ETA (rapid dissociation)	[44]

ADA: Adalimumab; ETA: Etanercept; GOL: Golimumab; IFX: Infliximab; Certo: Certolizumab pegol; PBL: peripheral blood lymphocytes; TNF: Tumor necrosis factor; mTNF: Membrane-bound TNF; sTNF: Soluble TNF; SPR: Surface plasmon resonance.

Citation: Billmeier U, Dieterich W, Neurath MF, Atreya R. Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases. World J Gastroenterol 2016; 22(42): 9300-9313
URL: https://www.wjgnet.com/1007-9327/full/v22/i42/9300.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i42.9300