Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy

Figure 3 Toll-like receptor-induced tumour necrosis factor, interleukin-1β, -6 and -10 in responders and non-responders compared to healthy controls. The differences in basal and stimulated (A) TNF, (B) IL-1β, (C) IL-6 and (D) IL-10 production in PBMCs post TLR stimulation. Results were calculated and expressed as fold-change from baseline (± SD). The P values represent statistical significance of < 0.05 between the groups as denoted. PBMC: Peripheral blood mononuclear cells; TLR: Toll-like receptor; TNF: Tumor necrosis factor; IL: Interleukin.