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©The Author(s) 2016.
World J Gastroenterol. Nov 7, 2016; 22(41): 9096-9103
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9096
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9096
Figure 1 Interleukin-17 signaling cascade and amplification loop.
IL-17 upregulates the production of pro inflammatory cytokines IL-6 and IL-23 through a complex intracellular signal involving IL-17 RA downstream Act1, MAPK and C/EBP transcription factors and kinases. IL-6 and IL-23 after binding their receptors, stimulate IL-17 production by PI3K and JAK/STAT3 that release NF-κB to translocate to the nucleus. IL-17: Interleukin-17; Act1: Activator 1; JAK/STAT3: Janus kinase/signal transducer and activator of transcription 3; PI3K: Phosphoinositide-3-kinase.
- Citation: Chackelevicius CM, Gambaro SE, Tiribelli C, Rosso N. Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis. World J Gastroenterol 2016; 22(41): 9096-9103
- URL: https://www.wjgnet.com/1007-9327/full/v22/i41/9096.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i41.9096