Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis

Table 2 Baseline characteristics of patients

Variable	Total cohort	28-d survivors	28-d nonsurvivors	P value
	(n = 264)	(n = 232)	(n = 32)
Age (yr)	48.8 ± 9.1	48.6 ± 9.2	48.3 ± 8.1	0.865
Men, n (%)	204 (77.3%)	175 (75.4%)	29 (90.6%)	0.070
Presence of cirrhosis, n (%)	240 (90.9%)	208 (89.7%)	32 (100%)	0.092
SIRS, n (%)	76 (28.8%)	63 (27.2%)	13 (40.6%)	0.144
Mean blood pressure (mmHg)	89.3 ± 15.9	90.1 ± 15.1	83.5 ± 20.0	0.082
WBC count (× 109/L)	9.6 ± 6.0	9.2 ± 5.9	12.0 ± 6.7	0.013
Platelet count (× 109/L)	109.2 ± 71.5	110.6 ± 72.0	98.7 ± 68.0	0.377
Albumin (g/dL)	2.7 ± 0.6	2.7 ± 0.5	2.3 ± 0.6	< 0.0001
Bilirubin (mg/dL)	11.3 ± 8.6	10.3 ± 8.0	18.7 ± 9.7	< 0.0001
AST (U/L)	157.7 ± 86.6	160.5 ± 88.4	137.3 ± 70.7	0.098
ALT (U/L)	49.9 ± 32.4	50.4 ± 33.3	46.4 ± 24.6	0.514
GGT (U/L)	428.4 ± 437.5	455.4 ± 448.4	236.9 ± 290.5	0.001
Prothrombin time (s)	18.0 ± 5.2	17.3 ± 3.9	22.8 ± 9.6	0.004
INR	1.7 ± 0.6	1.6 ± 0.4	2.3 ± 0.9	0.001
Creatinine (mg/dL)	1.2 ± 1.5	0.9 ± 0.7	2.9 ± 3.6	0.005
Sodium (mEq/L)	133.5 ± 6.6	133.8 ± 6.3	131.1 ± 8.2	0.078
DF score	38.8 ± 28.2	34.9 ± 21.6	68.4 ± 48.0	0.001
ABIC score	7.5 ± 1.4	7.3 ± 1.1	9.0 ± 1.9	< 0.0001
GAHS	7.4 ± 1.5	7.2 ± 1.3	9.1 ± 1.6	< 0.0001
MELD score	21.6 ± 6.9	20.3 ± 5.5	30.6 ± 9.1	< 0.0001
MELD-Na score	24.3 ± 6.8	23.1 ± 5.9	32.3 ± 7.2	< 0.0001
CLIF-SOFA score	6.8 ± 3.1	6.1 ± 2.1	11.5 ± 4.6	< 0.0001
CLIF-C OF score	7.9 ± 2.0	7.4 ± 1.4	11.2 ± 2.9	< 0.0001

Data are presented as mean ± SD or n (%). SIRS: Systemic inflammatory response syndrome; WBC: White blood cell; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyltransferase; INR: International normalized ratio; DF: Discriminant function; ABIC: Age, bilirubin, INR, creatinine; GAHS: Glasgow Alcoholic Hepatitis Score; MELD: Model for end-stage liver disease; MELD-Na: Modified MELD including sodium; CLIF-SOFA: Chronic Liver Failure-Sequential Organ Failure Assessment; CLIF-C OF: Chronic Liver Failure Consortium Organ Failure.