Presepsin teardown - pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis

Table 6 Association of presepsin, procalcitonin and C-reactive protein levels with short-term (28-d) mortality in patients with cirrhosis and bacterial infection

	Binary logistic regression analysis
	Univariate		Multivariate
	Unadjusted	P value	Adjusted for MELD	P value	Adjusted for leucocyte count	P value	Adjusted for MELD and leucocyte count	P value
ln(Presepsin)	3.59 (1.65-7.84)	0.001	1.9 (0.81-4.43)	0.138	2.91 (1.28-6.64)	0.011	1.61 (0.65-3.97)	0.303
ln(PCT)	2.54 (1.55-4.16)	< 0.001	1.89 (1.14-3.14)	0.014	2.33 (1.42-3.83)	0.001	1.81 (1.09-3.01)	0.022
ln(CRP)	2.17 (1.23-3.81)	0.007	1.73 (0.93-3.21)	0.081	1.84 (1.03-3.31)	0.040	1.56 (0.81-2.99)	0.180

Associations are expressed as odds ratios and 95%CI per 1 loge-unit increase. MELD: Model for end-stage liver disease; PCT: Procalcitonin; CRP: C-reactive protein.