Presepsin teardown - pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis

Table 5 Performance characteristics of presepsin, procalcitonin and C-reactive protein for prediction of short-term (28-d) mortality in patients with bacterial infection (n = 75)

Variable	Cut-off values	AUC-ROC (95%CI)	Sensitivity	Specificity	PPV	NPV	LR+	LR-
Presepsin (pg/mL)	1277	0.76 (0.64-0.85)	75.0%	69.1%	46.9%	88.4%	2.43	0.36
PCT (μmol/L)	0.48	0.87 (0.77-0.93)	90.0%	74.6%	56.2%	95.3%	3.54	0.13
CRP (mg/L)	39.6	0.74 (0.63-0.84)	75.0%	74.6%	51.7%	89.1%	2.95	0.34

PPV: Positive predictive value; NPV: Negative predictive value; LR+: Positive likelihood ratio; LR-: Negative likelihood ratio; PCT: Procalcitonin; CRP: C-reactive protein; MELD: Model for end-stage liver disease.