Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy

Table 4 Ulcerative colitis cohort demographics and characteristics

	UC non-responders (NR) (n = 12)	UC responders (R) (n = 12)	P value	Controls
			NR vs R	(n = 12)
Male:female	6:6	4:8	NS	4:8
Mean age at diagnosis (yr) (SD/range)	27.5 (12.2/15-59)	24.5 (8.8/10-36)	NS	N/A
Mean age at assessment (yr) (SD/range)	33.6 (14/20-67)	38.6 (14.2/21-64)	NS	33.4 (13/18-52)
Mean Disease duration (yr) (SD/range)	6.9 (2.7/13.1/20-67)	17.5 (10.6/4-37)	0.01	N/A
Median time of blood draw post-therapy (wk) (range)	156 (12-364)	208 (12-468)	NS	N/A
Montreal classification, n				N/A
Age at diagnosis (yr)
A1 - ≤ 16	1	1	NS
A2 - 17-40	9	10	NS
A3 - > 40	2	1	NS
Disease location
E1 - Proctitis	2	0	NS
E2 - Left sided	1	4	NS
E3 - Extensive	9	8	NS
Smoking status (n)
Never smoked	8	8	NS	8
Ex-smoker	3	4	NS	2
Current smoker	1	0	NS	2

UC: Ulcerative colitis.