Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy

Table 2 Clinical data of responders and non-responders

	Responders (n = 13) (n or mean ± SEM)	Non-responders (n = 5) (n or mean ± SEM)	P value
Immuno-suppressants
Thiopurine	10	4	NS
Tacrolimus	0	0
Prednisone	6	4	NS
Prednisone/thiopurine	5	2	NS
Methotrexate	0	0
5-ASA	1	2
Corticosteroids	9	2	NS
ESR	23.9 ± 4.8 (n = 11)	9.6 ± 2.2 (n = 4)	NS
CRP	25.8 ± 6.8 (n = 13)	9.2 ± 3.7 (n = 4)	NS
Partial Mayo1 (out of 9 - UC patients only)	8 ± 1.3 (n = 3)	8 (n = 3)	NS
CDAI (CD patients only)	321.9 ± 35.4 (n = 9)	385 ± 55 (n = 3)	NS

¹Partial Mayo scores presented, as not all patients had endoscopic examination at time of blood draw. CDAI: Crohn’s disease activity index; CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate; UC: Ulcerative colitis.