Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis

Table 3 Th17 in human tissues

	Th17 cells	Th17/Tregs	IL-17 expression	Disease	Ref.
Liver	↑	↑	↑	NAFLD - MO	Rau et al[4]
				PBC	Shi et al[62]
				CH - CIRR	Tan et al[46]
VAT			↑↑	MO	McLaughlin et al[59]
				MO	Zapata-Gonzalez et al[58]
SAT			↑	MAO	Fabbrini et al[57]
				MO	McLaughlin et al[59]
PBMC	↑↑↑	↑↑		NAFLD - MO	Rau et al[4]
				T2D	Zeng et al[60]
				Obesity	Łuczyński et al[64]
				PBC	Shi et al[62]

IL-17: Interleukin-17; Th17: IL-17 secreting T helper; Treg: Regulatory T cells; VAT: Visceral adipose tissue; SAT: Subcutaneous adipose tissue; PBMC: Peripheral blood mononuclear cells; NAFLD: Nonalcoholic fatty liver disease; MO: Morbid obesity; PBC: Primary biliary cirrhosis; CH: Chronic hepatitis; CIRR: Cirrhosis; T2D: Type II diabetes mellitus.