Copyright
©The Author(s) 2016.
World J Gastroenterol. Nov 7, 2016; 22(41): 9069-9095
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9069
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9069
Table 3 The characteristics of frequent recurrent somatic mutations and their correlations with clinical and pathological parameters in hepatocellular carcinoma based on deep-sequencing analyses
Gene | Altered pathway | Correlations with clinical and pathological parameters | Ref. |
TERT promoter | Telomere stability | Hepatocarcinogenesis | Nault et al[104]; Yang et al[165] |
TP53 | Cell cycle control | Under debate: an early event in the context of aflatoxin exposure and chronic HBV infection, or it might not play a role in carcinogenesis | Qi et al[136] |
Poor prognosis | El-Din et al[117] | ||
Cleary SP et al[138] | |||
CTNNB1 | Wnt/β-catenin signaling | Under debate: a late event for malignant progression or earlier during hepatocarcinogenesis | Park et al[253]; Vilarinho et al[256] |
Under debate: worse outcomes or better outcomes | Tornesello et al[263]; Wang et al[269] | ||
AXIN1 | Wnt/β-catenin signaling | Hepatocarcinogenesis and progression | Guan et al[242] |
ARID1A | Chromatin remodeling | Initiation and progression of HCC | Schulze et al[106] |
ARID2 | Chromatin remodeling | Initiation and progression of HCC | Totoki et al[107] |
NFE2L2 | Oxidative stress | Hepatocarcinogenesis and progression | Nault JC et al[105] |
KEAP1 | Oxidative stress | Hepatocarcinogenesis and progression | Schulze et al[106] |
JAK1 | JAK/STAT pathway | Hepatocarcinogenesis | Kan et al[28] |
RPS6KA3 | RAS/MAPK signaling | Hepatocarcinogenesis | Guichard et al[102] |
- Citation: Niu ZS, Niu XJ, Wang WH. Genetic alterations in hepatocellular carcinoma: An update. World J Gastroenterol 2016; 22(41): 9069-9095
- URL: https://www.wjgnet.com/1007-9327/full/v22/i41/9069.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i41.9069