Genetic alterations in hepatocellular carcinoma: An update

Table 2 Summary of single-nucleotide polymorphisms associated with the risk of hepatocellular carcinoma identified from genome-wide association studies

Related gene	SNP	Etiology of HCC	Odds ratio (95%CI)	P value	Ref.
TPTE2	rs2880301	HBV/HCV, Republic of Korea	0.27 (0.19-0.39)	1.74 × 10-12	Clifford et al[96]
KIF1B	rs17401966	HBV, China	0.61 (0.55-0.67)	1.70 × 10-18	Zhang et al[82]
KIF1B	rs17401966	HBV interacting with alcohol consumption, China	2.36 (1.49-3.74)		Chen et al[84]
GRIK1	rs455804	HBV, China	0.84 (0.80-0.89)	5.24 × 10-10	Li et al[94]
HLA-DQA1/DRB1	rs9272015	HBV, China	1.28 (1.22-1.35)	1.13 × 10-19	Li et al[94]
MICA	rs2596542	HCV, Japan	1.39 (1.27-1.52)	4.21 × 10-13	Kumar et al[91]
HLA-DQ	rs9275319	HBV, China	1.51 (1.38-1.66)	8.65 × 10-19	Jiang et al[97]
DEPDC5	rs1012068	HCV, Japan	1.75 (1.51-2.03)	1.27 × 10-13	Miki et al[90]
DDX18	rs2551677	HBV/HCV, Republic of Korea	3.38 (2.07-5.53)	1.41 × 10-10	Clifford et al[96]
FasL	rs763110	HBV/HCV, Egypt	1.970 (1.250-3.105)	0.003	Khalifa et al[98]
DLC1	rs3816747	HBV, China	0.486 (0.2450.962)/ 0.51 (0.2670.974)	0.037/0.039	Xie et al[99]
STAT4	rs7574865	HBV, China	1.22 (1.15-1.29)	1.66 × 10-11	Jiang et al[97]
FOXP3	rs3761549	HBV, China	1.32 (1.03-1.70)	0.030	Chen et al[100]

SNP: Single-nucleotide polymorphism; HCC: Hepatocellular carcinoma; GWAS: Genome-wide association studies; HBV: Hepatitis B virus; HCV: Hepatitis C virus; TPTE2: Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2; KIF1B: Kinesin-like factor 1 B; GRIK1: Glutamate receptor, ionotropic, kainate 1; HLA-DQA1/DRB1: Major histocompatibility complex, class II, DQ alpha 1, DR beta 1; MICA: MHC class I polypeptide-relatedsequence A; HLA-DQ: Major histocompatibility complex class II antigen; DEPDC5: DEP domain containing 5; DDX18: DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; FasL: Fas ligand; DLC1: Deleted in liver cancer 1; STAT4: Signal transducer and activator of transcription 4; FOXP3: Forkhead box P3.