Neuroendocrine neoplasms of liver - A 5-year retrospective clinico-pathological study applying World Health Organization 2010 classification

Figure 2 G1-G3 neuroendocrine neoplasms. A: G1 - tumor with trabecular and nested pattern (H&E × 200); B: Tumor cells displaying Ki-67 index of < 1% (immunohistochemistry × 200); C: G2 - tumor with gyriform and festooning patterns and the tumor cells display mildly pleomorphic nuclei with coarse stippled chromatin (H&E × 200); D: Tumor cells displaying Ki-67 index of approximately 16% (immunohistochemistry × 200); E: G3 - tumor cells with pleomorphic and hyperchromatic nuclei displaying brisk mitotic (arrow) and apoptotic activity and focal necrosis (arrow head) (H&E × 200); F: Tumor cells displaying Ki-67 index of approximately 80% (immunohistochemistry × 200); G: Tumor cells displaying diffuse cytoplasmic positivity for synaptophysin (immunohistochemistry × 200); H: Tumor cells displaying diffuse cytoplasmic positivity for chromogranin (immunohistochemistry × 200).