Establishment of various biliary tract carcinoma cell lines and xenograft models for appropriate preclinical studies

doi:10.3748/wjg.v22.i40.9035

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2016; 22(40): 9035-9038
Published online Oct 28, 2016. doi: 10.3748/wjg.v22.i40.9035

Table 2 Sensitivity to gemcitabine in each cell line

Cell line	Sensitivity to gemcitabine in cell line¹
Cell line	IC₅₀ (μmol/L)	IC₆₀ (μmol/L)	IC₇₀ (μmol/L)	IC₈₀ (μmol/L)
NCC-CC1	86.78	N.A	N.A	N.A
NCC-CC3-1	0.04	1.82	9.31	85.21
NCC-CC3-2	0.10	1.92	43.83	N.A
NCC-CC4-1	0.05	4.08	N.A	N.A
NCC-CC4-2	0.03	11.53	N.A	N.A
NCC-CC4-3 (NCC-CC5)	0.06	4.92	95.10	N.A
NCC-CC6-1	0.01	0.02	0.06	3.76
NCC-CC6-2	10.98	35.67	N.A	N.A
NCC-BD1	7.66	58.00	N.A	N.A
NCC-BD2	N.A	N.A	N.A	N.A
NCC-BD3	N.A	N.A	N.A	N.A
NCC-BD4-1	0.04	0.06	0.09	2.93
NCC-BD4-2	0.06	0.07	0.19	5.37

¹The cytotoxicity of gemcitabine for each cell line was assessed by a modified 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt assay with CellTiter 96 Aqueous One Solution Reagent (Promega, Madison, WI, United States). Tumor cells (3000 cells⁄well) in the exponential growth phase were grown in 96-well plates. IC: Inhibitory concentration.

Citation: Ojima H, Yamagishi S, Shimada K, Shibata T. Establishment of various biliary tract carcinoma cell lines and xenograft models for appropriate preclinical studies. World J Gastroenterol 2016; 22(40): 9035-9038
URL: https://www.wjgnet.com/1007-9327/full/v22/i40/9035.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i40.9035