Antioxidant and anti-inflammatory action of melatonin in an experimental model of secondary biliary cirrhosis induced by bile duct ligation

Table 1 Plasma levels of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase in the different experimental groups

Group	AST (U/L)	ALT (U/L)	AP (U/L)
CO	88.8 ± 0.07	37.0 ± 1.9	122.4 ± 13.5
CO + Mel	90.4 ± 8.4	38.8 ± 3.2	111.6 ± 8.1
BDL	425.8 ± 46.6e	105.8 ± 13.5e	381.2 ± 35.5e
BDL + Mel	117.5 ± 18.8f	42.0 ± 3.4f	104.3 ± 11.03f

All concentrations are expressed as mean ± SD error. Significant difference exists between the BDL and control groups (CO and CO + Mel) (^eP < 0.001). Significant difference exists between the BDL and BDL + Mel groups (^fP < 0.001). CO: Control; CO + Mel: Control + melatonin; BDL: Bile duct ligation; BDL + Mel: Bile duct ligation + melatonin.