Polymorphisms and resistance mutations of hepatitis C virus on sequences in the European hepatitis C virus database

doi:10.3748/wjg.v22.i40.8910

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Oct 28, 2016; 22(40): 8910-8917
Published online Oct 28, 2016. doi: 10.3748/wjg.v22.i40.8910

Table 4 Resistance associated variants conferring resistance to direct antiviral agents¹

	euHCVdb		Los Alamos
	1a	1b	1a	1b
DAA	RAV	RAV	RAV	RAV
NS3
Simeprevir	V36M (0.32%)		V36M (0.44%)
	Q80K (44.66%)	Q80L (6.39%)	Q80K (36.62%)	Q80L (6.02%)
	S122G (4.49%)	S122G (9.07%)	n.a	n.a
	R155K (0.64%)		R155K (0.88%)
	D168E (0.32%)	D168E (0.98%)	D168E (0.29%)	D168E (0.80%)
				D170T (0.20%)
Paritaprevir	R155K (0.64%)		R155K (0.88%)
	D168E (0.32%)	D168E (0.98%)	D168E (0.29%)	D168E (0.80%)
Grazoprevir	A156T (0.00%)	A156T (0.00%)	A156T (0.00%)	A156T (0.00%)
	D168E (0.32%)	D168E (0.98%)	D168E (0.29%)	D168E (0.80%)
NS5A
Ledipasvir	M28T (0.75%)		n.a	n.a
	Q30H (1.47%)
	Q30R (0.37%)
	L31M (1.12%)
	Y93H (0.74%)	Y93H (4.25%)
	Y93C (0.37%)
Daclatasvir	M28T (0.75%)		n.a	n.a
	Q30H (1.47%)
	Q30R (0.37%)
	Y93H (0.74%)	Y93H (4.25%)
Ombitasvir	M28V (4.49%)	Y93H (4.25%)	n.a	n.a
Elbasvir	Q30H (1.47%)
	L31M (1.12%)
	Y93H (0.74%)	Y93H (4.25%)
NS5B
Sofosbuvir	S282T (0.00%)	S282T (0.00%)	S282T (0.00%)	S282T (0.00%)
Dasabuvir		C316N (37.02%)		C316N (36.17%)
		C316Y (0.32%)		C316Y (0.30%)
		N556G (7.82%)	N556G (0.42%)	N556G (8.21%)

¹DAAs recommended by the EASL and AASLD guidelines 2015. RAV: Resistance associated variants; DAAs: Direct antiviral agents; AASLD: American Association for the Study of Liver Diseases.

Citation: Kliemann DA, Tovo CV, da Veiga ABG, de Mattos AA, Wood C. Polymorphisms and resistance mutations of hepatitis C virus on sequences in the European hepatitis C virus database. World J Gastroenterol 2016; 22(40): 8910-8917
URL: https://www.wjgnet.com/1007-9327/full/v22/i40/8910.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i40.8910