Polymorphisms and resistance mutations of hepatitis C virus on sequences in the European hepatitis C virus database

Table 3 Main amino acid substitutions found in the hepatitis C virus NS5A protease

	Amino acid (frequency %)
	HCV genotype
	1a				1b								2a	2b	3a
Position	wt				wt								wt	wt	wt
282	S	99.40	R	0.60	S								S	S	S
316	C				N	37.02	C	62.34	R/Y	0.32			C	C	C
556	S				N	89.24	D	0.98	G	7.82	N	1.95	G	G	G

Amino acid in bold are associated with resitance. wt: Wild-type; HCV: Hepatitis C virus.