Liver-targeted hydrodynamic gene therapy: Recent advances in the technique

doi:10.3748/wjg.v22.i40.8862

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Oct 28, 2016 (publication date) through Nov 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Therapeutics Advances

World J Gastroenterol. Oct 28, 2016; 22(40): 8862-8868
Published online Oct 28, 2016. doi: 10.3748/wjg.v22.i40.8862

Table 2 Summary of the applications of hydrodynamic delivery for functional analysis of therapeutic genes related to the diseases of gastroenterology and hepatology

Disease	Therapeutic Genes	Ref.
Nonalcoholic steatohepatitis	Inducible nitric oxcide synthetase	[8]
Hepatitis	HBV knockdown	[5,9]
	HCV knockdown
Fulminant hepatitis	NKG2D knockdown	[7,10]
	osteopontin knockdown
Liver injury	c-met	[7,11]
	IL-37
	caspase knockdown
Liver fibrosis	platelet-derived growth factor receptor beta knockdown	[12]
Liver Regeneration	fibroblast growth factor 7	[13]
Fabry disease	alpha-galactosidase A	[7]
Pancreatitis	pancreatitis associated protein 1	[14]
Colon cancer	IL-15	[15]

HBV: Hepatitis B virus; HCV: Hepatitis C virus; IL: Interleukin.

Citation: Yokoo T, Kamimura K, Abe H, Kobayashi Y, Kanefuji T, Ogawa K, Goto R, Oda M, Suda T, Terai S. Liver-targeted hydrodynamic gene therapy: Recent advances in the technique. World J Gastroenterol 2016; 22(40): 8862-8868
URL: https://www.wjgnet.com/1007-9327/full/v22/i40/8862.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i40.8862